Many drug hypersensitivity reactions are HLA-linked, meaning that they will occur much more often or even exclusively in individuals who have certain variants of the HLA gene. A new study elucidates the specific mechanism leading to HLA gene-linked hypersensitivity to the drug abacavir. These findings are applicable to other drugs and related hypersensitivity reactions.
The findings are discussed in the paper “Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire,” published last week in the scientific journal Proceedings of the National Academy of Sciences.
An interview with the authors is published in the Source cited below.
Source: Clinical Toxicology