Seventh Wave Laboratories now offer a battery of gastrointestinal (GI) preclinical models (TIM) to help clients to assess the behavior of oral medications. The in vitro models are licensed from TNO, a Dutch contract research organization. The TIM system has proven useful in solving specific needs in formulation development and pharmacokinetics.
By accurately simulating the conditions in the human GI tract, the TIM system gives insight into the release, solubility, and availability for absorption of pharmaceuticals. This state-of-the-art, validated system has a much higher predictive value than regular dissolution tests. The computer-regulated model can simulate various physiologic states and helps scientists to determine the bioaccessibility of active compounds and predict resultant blood concentration after single or repeated intake of various dosage forms.